The purpose of the current study is to evaluate the efficacy of d-cycloserine in augmenting treatment of smoking cessation for individuals with panic attacks. Individuals will receive 7 weeks of panic- and smoking-reduction treatment (PSRT) and one pill of d-cycloserine (DCS) or one pill placebo one hour prior to sessions 3, 4, and 5 (i.e., 3 single doses). Participants will also be given nicotine replacement therapy as part of PSRT (i.e., the patch).
- Male and female patients ages 18 to 65 capable of providing informed consent
- Willing and able to provide informed consent, attend all study visits and comply with the protocol
- Daily smoker for at least one year
- Currently smoke an average of at least 10 cigarettes per day
- Report a motivation to quit smoking in the next month of at least 5 on a 10-point scale
- Evidence of panic attack within the past year and endorsement of smoking as an emotion regulation strategy (i.e., score at least a 78 on the SAEQ).
- Subjects who do not use smoking as an emotion-regulation strategy
- Current diagnosis of a psychotic, eating, developmental, or bipolar disorder
- Significant suicide risk as determined by structured interview
- Pregnant women, lactating women, and women of childbearing potential who are not using medically accepted forms of contraception (e.g., IUD, oral contraceptives, barrier devices, condoms and foam, or implanted progesterone rods stabilized for at least 3 months)
- Psychoactive substance abuse or dependence (excluding nicotine dependence) within the past 6 months
- Current use of isoniazid or ethionamide compounds
- A history of significant medical condition and/or be deemed as currently unhealthy in the context of a complete physical examination
- Limited mental competency and the inability to give informed, voluntary, written consent to participate
- Current use of any pharmacotherapy or psychotherapy for smoking cessation not provided by the researchers during the quit attempt
- Concurrent psychotherapy initiated within three months of baseline, or ongoing psychotherapy of any duration directed specifically toward treatment of anxiety or mood disorder other than general supportive therapy initiated at least 3 months prior to the study
- Use of other tobacco products
- Plans to move outside of the immediate area in the next 6 months
- Insufficient command of the English language
ADAA member Dr. Richard Heimberg, director of the Adult Anxiety Clinic of Temple University, explains social anxiety disorder, which affects more than 15 million Americans.
ADAA produced these videos in association with the Andrew Kukes Foundation for Social Anxiety.
Five new video segments to watch about understanding and overcoming social anxiety disorder.
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Read Huffington Post blog posts written by ADAA members:
It is appropriate and expected to ask questions during a brief telephone, email, or in-person consultation to see if a treatment provider is the right one for you. Before he or she can respond to some of your questions, you may be asked to give your age, your diagnosis or the problems you are seeking help with, as well as any treatment history.
Drawing on his own long-standing battle with anxiety, Scott Stossel, author of My Age of Anxiety: Fear, Hope, Dread, and the Search for Peace of Mind, presents the history and efforts to understand an affliction that is pervasive yet often misunderstood. Watch his conversation with talk show host Mimi Geerges.Watch
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