At the Intersection: Mood or Anxiety Disorders and Substance Use Disorder

Janssen_Cons_RGB_0_0.jpgSupported by Janssen

Friday, April 7

2:30 – 6:00 pm

The Scientific Research Symposium (SRS) will bring together experts in the field to highlight links between mood or anxiety disorders and substance use from genetics, psychological, epidemiological, and treatment perspectives.  The goal is to provide a comprehensive overview of the state of knowledge and discuss insights from the experts toward the development of new ways of identifying, individuals at risk, determining what treatments might be effective, and develop tools to quantify the prognosis of patients with mood, anxiety and comorbid substance use disorder.

Substance use is highly comorbid with mood1and anxiety2 disorders. Substance use emerges during early teens and twenties (see figure 1), but there are also indications that illicit drug use is on the rise among the elderly (see figure 2). Several neurobiological theories have been proposed for the increased incidents during adolescents, which involve the imbalance between increased reward-related processing and inadequate cognitive control3, which emphasis positive reinforcement processes4. On the other hand, there is also evidence that substance use and maintenance emerges because the individual aims to relieve aversive and painful conditions, which has been termed antireward processing5.


Martin-Paulus_0.jpgMartin P. Paulus, MD — Chair

Laureate Institute for Brain Research


Genome-Wide Association Study of Post-Cannabis Dependence Anxiety

Joel-Gelernter_0.jpgJoel Gelernter, MD

Yale University School of Medicine

Self-Medication of Mood and Anxiety Symptoms with Alcohol and Drugs: Findings from Large Scale Epidemiologic Surveys

Jitender-Sareen_0.jpgJitender Sareen, MD

University of Manitoba


Drinking to Cope: Psychological Mechanisms of Substance Use

Sherry-Stewart_0.jpgSherry Stewart, PhD

Dalhousie University

Smoking and Trauma


Mark Powers, PhD

The University of Texas at Austin


1.            Cranford, J.A., Nolen-Hoeksema, S. & Zucker, R.A. Alcohol involvement as a function of co-occurring alcohol use disorders and major depressive episode: evidence from the National Epidemiologic Survey on Alcohol and Related Conditions. Drug Alcohol Depend 117, 145-51 (2011).

2.            Kessler, R.C., Ruscio, A.M., Shear, K. & Wittchen, H.U. Epidemiology of anxiety disorders. Curr Top Behav Neurosci 2, 21-35 (2010).

3.            Casey, B.J., Jones, R.M. & Hare, T.A. The adolescent brain. Ann N Y Acad Sci 1124, 111-126 (2008).

4.            Goldstein, R.Z. & Volkow, N.D. Dysfunction of the prefrontal cortex in addiction: neuroimaging findings and clinical implications. Nat Rev Neurosci 12, 652-69 (2011).

5.            Koob, G.F. Negative reinforcement in drug addiction: the darkne within. Curr Opin Neurobiol 23, 559-63 (2013).