Attaining and Maintaining Wellness in OCD (#6628)

A research study offering treatment for people who have obsessive-compulsive disorder (OCD) and are currently taking one of the following medications and still have unwanted symptoms:

  • Clomipramine (Anafranil)
  • Fluoxetine (Prozac)
  • Fluvoxamine (Luvox)
  • Sertraline (Zoloft)
  • Paroxetine (Paxil)
  • Citalopram (Celexa)
  • Escitalopram (Lexapro)

The goal of the study is to understand whether patients with OCD on serotonin reuptake inhibitors (SRIs) who achieve wellness from EX/RP can safely discontinue their medication.

Eligible participants initially remain on a stable dose of their OCD medication and will receive cognitive-behavioral therapy (CBT) consisting of exposure and ritual prevention (EX/RP) twice a week for up to 12 weeks as additional treatment. 

Participants who become well (minimal-to-mild OCD symptoms) after the EX/RP will be randomly assigned to either continue their medication or begin to taper off their medication and have it gradually replaced with a placebo. 

All patients will be carefully monitored throughout the study for 24 weeks. No one who has not become well after 12 weeks of EX/RP will discontinue their medication. Individuals who do not improve significantly will be referred elsewhere to receive appropriate clinical treatment.

Organization: 
University of Pennsylvania
Principal Investigator: 
Edna Foa, PhD
Eligibility Criteria: 

You may be eligible if

  • You have OCD.
  • You are between the ages of 18 and 75.
  • You are still having bothersome symptoms while taking one of the medications listed below for OCD.
  • You are interested in receiving no-cost therapy treatment that may improve your symptoms so that you may be able to stop taking your medication.
  • Clomipramine (Anafranil)
  • Fluoxetine (Prozac)
  • Fluvoxamine (Luvox)
  • Sertraline (Zoloft)
  • Paroxetine (Paxil)
  • Citalopram (Celexa)
  • Escitalopram (Lexapro)
Contact: 
212-543-5462 or 212-543-5367
Location: 
3535 Market Street, Philadelphia, PA 19104
State: 
Pennsylvania

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ADAA is a national nonprofit organization dedicated to the prevention, treatment, and cure of anxiety, OCD, PTSD, depression, and related disorders and to improving the lives of all people who suffer from them.