Children

Treating Children With PTSD

Judith Cohen, MD

Medical Director, Center for Traumatic Stress in Children & Adolescents
Allegheny General Hospital
Pittsburgh, Pennsylvania

Professor of Psychiatry
Drexel University College of Medicine

Dr. Cohen discusses how children experience PTSD and effective treatments.

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New Personal Story of Overcoming OCD

7/15/2011

OCD burdened a bright young woman for more than 10 years. Read all about her recovery and her advice to others who are suffering in Working Toward Compassion and Moderation.

“I advise anyone dealing with OCD to find a competent therapist who specializes in this illness.”

The Throes of Severe OCD: a Mother’s Perspective

My son Dan was in college, and by the time I arrived at his dorm, he had not eaten in more than a week. He was spending hours at a time sitting in one particular chair, hunched over with his head in his hands, doing absolutely nothing. He could not enter most of the buildings on campus and could only do minimal amounts of work at specific times. To top it all off, he was self-injuring. My son was in the throes of severe OCD.

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Anxiety Disorders (Pediatric) Research Study

This study examines whether an antibiotic, d-cycloserine (DCS), boosts the effectiveness of cognitive behavior therapy (CBT) for social anxiety. CBT has been shown to be effective for the treatment of social anxiety in children and adults, but even after treatment, approximately 40% may remain diagnosable. All participants will receive 12 weekly CBT sessions. In addition to receiving the CBT, participants will be randomly assigned (similar to a coin toss) to receive either DCS or a placebo (sugar pill). The pill will be taken 1-2 hours prior to each of the 12 CBT sessions.

Organization: 
NIMH
Principal Investigator: 
Jennifer A. Cameron, Ph.D.
Eligibility Criteria: 
  1. Subjects between 8 yrs of age (preadolescents) and under 55 yrs of age.
  2. Subjects medically healthy.
  3. Able to give informed consent.
  4. Not on psychotropic meds for a minimum of 6 weeks for fluoxetine; a minimum of 1 week for PRN benzodiazepines and beta blockers, and a minimum of 3 weeks for all other psychotropic meds.
  5. Subjects diagnosed with DSM IV symptoms of social phobia, generalized or specific type.
Exclusion Criteria: 
  1. Current major depressive disorder.
  2. Lifetime diagnosis of psychotic disorder, bipolar disorder, eating disorder, mental retardation, substance or alcohol dependence (other than nicotine); active suicidal ideation.
  3. Current or lifetime history of a neurological disorder (other than tic disorders, febrile seizures of infancy), seizure disorder.
  4. Any unstable medical condition.
  5. Use of any psychoactive substance in the past 30 days.
Contact: 
(800) 411-1222, prpl@mail.cc.nih.gov
Location: 
Bethesda, MD
State: 
Maryland

Anxiety Disorders (Pediatric) Research Study

This study uses functional magnetic resonance imaging (fMRI) to learn how the brain functions in adolescents receiving fluoxetine (Prozac) or cognitive behavioral therapy (CBT) for anxiety or depression in children/adolescents. All participants will receive interviews to assess how they are doing in general, including his or her general mood, degree of nervousness and behavior. Each participant and one of his or her parents will be interviewed separately and together.

Organization: 
NIMH
Principal Investigator: 
Daniel S. Pine, MD; 301-594-9960, Daniel.Pine@nih.hhs.gov
Eligibility Criteria: 

JUVENILE SUBJECTS

Age: 8 to 17

Consent: Can give consent/assent. (Parents will provide consent; minors will provide assent.)

IQ: All subjects will have IQ greater than 70 (Assessment relies on WASI)

SUBJECTS WITH AN ANXIETY DISORDER

Diagnosis: Current Diagnosis of Social Phobia, Separation Anxiety, or Generalized Anxiety Disorder (Based on K-SADS)

Symptom Severity: Score greater than 9 on PARS (This score was used to enroll subjects in previous trial demonstrating efficacy of an SSRI in pediatric anxiety.)

Clinical Impairment: CGAS less than 60

SUBJECTS WITH A MOOD DISORDER

Diagnosis: Current Diagnosis of Major Depression (Based on K-SADS (juveniles) or SCID (adults))

Clinical Impairment: CGAS less than 60 (juveniles) GAS less than 70 (adults)

Symptom Severity: CDRS Score greater than 39 (juveniles) (This score was used to enroll subjects in previous trials demonstrating efficacy of an SSRI in pediatric depression.)

ADULT SUBJECTS

Age: 20-40

Consent: Can give consent/assent.

IQ: All subjects will have IQ greater than 70. Assessment relies on WASI.

Exclusion Criteria: 

ALL SUBJECTS:

Any serious medical condition or condition that interferes with fMRI scanning, and for patients electing medication, any condition that increases risk of SSRI treatment. All patients will have complete physical examination. Healthy volunteer participants will be medication-free and have no current serious medical conditions, based on a review of their medical history.

Pregnancy

Current use of any psychoactive substance; current suicidal ideation; current diagnosis of attention deficit hyperactivity disorder (ADHD) of sufficient severity to require pharmacotherapy. These factors could complicate treatment with an SSRI. No subject on medication will be accepted into the trial. Subjects will not be taken off of medications to enter the trial.

Current diagnoses: Tourette's, OCD, posttraumatic distress disorder, conduct disorder. These factors may be effected by SSRI treatment, influencing ability to detect effects on anxiety/depression

Past or current history of mania, psychosis, or pervasive developmental disorder. These factors may be effected by SSRI treatment, influencing ability to detect effects on anxiety/depression

Recent use of an SSRI: All subjects must have been free of any SSRI use for at least one month (fluoxetine six months) and must not have been treated with an SSRI for their current depressive episode. This is designed to exclude subjects who have failed a trial of an SSRI for their current episode of major depression.

HEALTHY ADULT SUBJECTS

Any current psychiatric diagnosis. Assessment relies on SCID.

SUBJECTS WITH AN ANXIETY DISORDER

Current Major Depressive Disorder

Contact: 
Allison M. Detloff, 301-451-6817, detloffa@mail.nih.gov
Location: 
Bethesda
State: 
Maryland
Study End Date: 
Tue, 2013-12-31

News and Research

Cognitive-Behavior Therapy in Occupational Therapy

There has been an increasing trend in pediatric clients with mood disorders entering occupational therapy over the last few years. One practitioner discusses using cognitive-behavioral therapy (CBT), among other strategies, for pediatric clients. (Advance, 28(15):17)  Read more.

5-day intensive treatment for childhood OCD

Are you having trouble finding treatment for your child or teenager with obsessive-compulsive disorder?

Organization: 
Mayo Clinic, University of South Florida, Fordham University
Principal Investigator: 
Stephen Whiteside, PhD; Eric Storch, PhD; Dean MaKay, PhD
Eligibility Criteria: 

Your child must be between the ages of 7 and 17 and have problematic OCD symptoms. In addition, at least one parent is needed to accompany the child and the family must have a computer with high-speed internet within their home.

To participate in this study you and your child must travel to one of three sites: Mayo Clinic in Rochester, MN; University of South Florida in Tampa, FL; or Fordham University in Bronx, NY.

Exclusion Criteria: 

Patients must not have history of and/or current psychosis, autism, bipolar disorder, oppositional defiant disorder, or eating disorder, or be suicidal. Participants can be included if they are taking medications for OCD provided that no changes are made during the study.

Contact: 
Stephen Whiteside, PhD, (507) 293-0089, whiteside.stephen@mayo.edu; Eric Storch, PhD, (727) 767-8230, estorch@health.usf.edu; Dean McKay,PhD, (718) 817-4498, mckay@fordham.edu
Location: 
Bronx, NY
State: 
New York

5-day intensive treatment for childhood OCD

Are you having trouble finding treatment for your child or teenager with obsessive-compulsive disorder?

Organization: 
Mayo Clinic, University of South Florida, Fordham University
Principal Investigator: 
Stephen Whiteside, PhD; Eric Storch, PhD; Dean MaKay, PhD
Eligibility Criteria: 

Your child must be between the ages of 7 and 17 and have problematic OCD symptoms. In addition, at least one parent is needed to accompany the child and the family must have a computer with high-speed internet within their home.

To participate in this study you and your child must travel to one of three sites: Mayo Clinic in Rochester, MN; University of South Florida in Tampa, FL; or Fordham University in Bronx, NY.

Exclusion Criteria: 

Patients must not have history of and/or current psychosis, autism, bipolar disorder, oppositional defiant disorder, or eating disorder, or be suicidal. Participants can be included if they are taking medications for OCD provided that no changes are made during the study.

Contact: 
Stephen Whiteside, PhD, (507) 293-0089, whiteside.stephen@mayo.edu; Eric Storch, PhD, (727) 767-8230, estorch@health.usf.edu; Dean McKay,PhD, (718) 817-4498, mckay@fordham.edu
Location: 
Tampa, FL
State: 
Florida

5-day intensive treatment for childhood OCD

Are you having trouble finding treatment for your child or teenager with obsessive-compulsive disorder?

Organization: 
Mayo Clinic, University of South Florida, Fordham University
Principal Investigator: 
Stephen Whiteside, PhD; Eric Storch, PhD; Dean MaKay, PhD
Eligibility Criteria: 

Your child must be between the ages of 7 and 17 and have problematic OCD symptoms. In addition, at least one parent is needed to accompany the child and the family must have a computer with high-speed internet within their home.

To participate in this study you and your child must travel to one of three sites: Mayo Clinic in Rochester, MN; University of South Florida in Tampa, FL; or Fordham University in Bronx, NY.

Exclusion Criteria: 

Patients must not have history of and/or current psychosis, autism, bipolar disorder, oppositional defiant disorder, or eating disorder, or be suicidal. Participants can be included if they are taking medications for OCD provided that no changes are made during the study.

Contact: 
Stephen Whiteside, PhD, (507) 293-0089, whiteside.stephen@mayo.edu; Eric Storch, PhD, (727) 767-8230, estorch@health.usf.edu; Dean McKay,PhD, (718) 817-4498, mckay@fordham.edu
Location: 
Rochester, MN
State: 
Minnesota

Bipolar Disorder in Children and Teens

Children and teens with bipolar disorder experience unusual and extreme mood changes, which can affect energy and behavior. These changes are different from  normal childhood and adolescent ups and downs. At times, those with bipolar disorder feel very happy and are much more active than usual. But other times, they feel extremely sad and are much less active.

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Silver Spring, MD 20910

240.485.1001

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ADAA is a national nonprofit organization dedicated to the prevention, treatment, and cure of anxiety, OCD, PTSD, depression, and related disorders and to improving the lives of all people who suffer from them.