This study is investigating what, if any, changes in brain chemistry take place in adults with OCD as a result of cognitive behavioral therapy (CBT). We will measure amounts and distribution of glutamate in the brain using MRSI (Magnetic Resonance Spectroscopic Imaging) scans before and after 4 weeks of CBT.
The study offers:
Listen to this podcast to find out about CBT, or cognitive-behavioral therapy, and how therapists use it to treat anxiety and related disorders.
Meets first Wednesday of each month; 7:00–8:30 pm
Need more help for your OCD? Many people with OCD experience only a partial response to currently available medications.
Montefiore Medical Center and multiple sites across the U.S. are seeking volunteers to participate in a clinical trial evaluating the effectiveness of low-dose ondansetron augmentation for the treatment of
Participants must have a DSM-IV-TR diagnosis of OCD as their primary disorder who have been on a stable treatment regimen of clomipramine, fluvoxamine, fluoxetine, paroxetine or sertraline for at least 6 weeks may be eligible for this study. Six additional weeks of stable SRI treatment, without adequate clinical response, will be required prior to randomization, after which the participant will receive SRI plus study drug, for a total of 12 more weeks.
Exclusion criteria include, but are not restricted to the following:
• Failure to respond to more than 2 SRI treatments prior to current SRI
• Hoarding as primary OCD symptom
• Current or past medical history of schizophrenia or other psychotic disorders, schizotypal personality disorder, bipolar disorder, Tourette syndrome, autism or autistic spectrum disorders, eating disorders, PTSD
• Requiring active behavioral therapy
• History of drug addiction or drug, alcohol or other substance abuse within the past 12 months
• Currently taking, or having taken within the previous 8 weeks, any of the following: other SRls, antipsychotic drugs, lithium, benzodiazepines or other anxiolytics, carbamazepine, oxcarbazepine, phenytoin, or other anti-depressants (including St. John's Wort)
• Likely to use triptans at any time during the study
• Believed to have suicidal or homicidal risk
People often jokingly point to odd habits or tidiness as signs of obsessive-compulsive disorder, or OCD. But the truth is OCD is a very real disorder that affects more than 2 million Americans, and there is a big difference between maintaining a morning routine or keeping a clean home and living with the disorder.
We at the Bio-Behavioral Institute in Great Neck, NY are investigating the role of certain emotions in individuals with body dysmorphic disorder (BDD), obsessive-compulsive disorder (OCD), or hoarding.
Individuals who have been diagnosed with one or more of the following:
OCD burdened a bright young woman for more than 10 years. Read all about her recovery and her advice to others who are suffering in Working Toward Compassion and Moderation.
Episodic OCD burdened me for over a decade, from my college yea