A number of studies using different techniques have suggested that the neurotransmitter glutamate is present at excessive levels in at least some patients with OCD. This idea has motivated our use of glutamate-modulating drugs in OCD that has not responded to standard therapies. However, the details of how glutamate is out of balance in OCD remain unclear. Likewise, it is unclear whether glutamate dysregulation contributes to all forms of OCD or only to some subtypes.
Diagnosed with Obsessive-Compulsive Disorder
This study aims to determine whether adding a medication called minocycline to
antidepressant treatment can help reduce symptoms of OCD. This study also aims to
learn more about the brains of children and adolescents with OCD.
Your child must be taking a stable dose of a serotonin reuptake inhibitor (SRI) in order to
participate in this study. During the 12 week study period, your child will continue to
• 8 - 20 years
• Genders: both
• Key inclusion criteria: Primary diagnosis of OCD and currently on a stable and adequate dose of an SRI
Your child may be eligible to participate in this study if he/she is diagnosed with Obsessive-Compulsive Disorder.
• Lifetime diagnosis of: psychotic disorder, bipolar disorder, eating disorder, pervasive developmental disorder, mental retardation, or substance/alcohol dependence
• Current diagnosis of major depressive disorder, attention-deficit hyperactivity disorder (ADHD), Tourette’s/Tic Disorder, or substance/alcohol abuse
• Diagnosis of pediatric autoimmune neuropsychiatric disorders associated with streptococcus (PANDAS)
• Active Suicidal Ideation
• Hoarding as the primary OCD symptom
• Pregnant, nursing, or planning to become pregnant
Listen to Dr. Dennis Greenberger describe the differences and similarities between symptoms of anxiety and depression, how the disorders are treated, and what patients can expect in treatment.
Dennis Greenberger, PhD
Founder and Director
Anxiety & Depression Center
Newport Beach, California
Assistant Clinical Professor
Department of Psychiatry
University of California, Irvine, College of Medicine
Dr. Greenberger describes the differences and similarities between symptoms of anxiety and depression, how the disorders are treated, and what patients can expect in treatment.
A research study offering treatment for people who have obsessive-compulsive disorder (OCD) and are currently taking one of the following medications and still have unwanted symptoms:
The goal of the study is to understand whether patients with OCD on serotonin reuptake inhibitors (SRIs) who achieve wellness from EX/RP can safely discontinue their medication.
You may be eligible if
- Clomipramine (Anafranil)
- Fluoxetine (Prozac)
- Fluvoxamine (Luvox)
- Sertraline (Zoloft)
- Paroxetine (Paxil)
- Citalopram (Celexa)
- Escitalopram (Lexapro)
A research study comparing patients with OCD to patients with several other disorders to help us understand the differences in the neurocircuitry of the brain across disorders.
This study uses different behavioral tasks and questionnaires to measure participants’ stress reactivity, startle reflexes, and preferences. All information will be kept completely confidential.
You may be eligible if
You must be able to travel to the New York State Psychiatric Institute/Columbia University at 1051 Riverside Drive (at 168th Street) in Manhattan.
A successful young woman breaks free from her "prison" of panic and OCD, thanks to her search for treatment. "So often, people who suffer from anxiety are laughed at as weak or neurotic. I’d like to think we’re actually pretty strong: It takes a lot to silently control a ping-ponging mind." Read on.
Back in 2006, I had it all: A loving fiancé, a coveted publishing job, a supportive network of friends and family. I was living in Washington, D.C., where I went out almost every night to press parties and trendy restaurants. In my spare time, I delivered meals on wheels and counseled Alzheimer’s patients at the local senior center. Perfectionistic and ever so vigilant, I could’ve won the Perfect Life Olympics.Read
Over the course of 17 weeks, participants in this study will use an internet program designed for treating OCD. They will meet with a therapist 9 times during the treatment. All participants will receive the treatment.
Individuals with the following may be considered for the study:
Individuals with the following will not be considered for the study:
Do you have obsessive-compulsive disorder or think you might? Have you had trouble finding treatment for your OCD? Do you use the Internet? If you answered “yes” to these questions, you might be eligible to participate in a research study conducted by Dr. Kenneth Kobak of the Center for Psychological Consultation.
To participate in this study, you must be at least 18 years old, have OCD, and use or be willing to use the Internet. You will not be required to travel to participate in this study, as the BT Steps program is web-based and all coaching will take place via telephone. Participants will be compensated up to $250 for their participation.