Need more help for your OCD? Many people with OCD experience only a partial response to currently available medications.
Emory University and multiple sites across the U.S. are seeking volunteers to participate in a clinical trial evaluating the effectiveness of low-dose ondansetron augmentation for the treatment of OCD in patients who have not adequately responded to their current SRI therapy after at least 12 weeks of stable treatment.
Eligible participants will be randomly assigned to receive ondansetron 0.5 mg, ondansetron 0.75 mg, or placebo, twice daily. Participants will continue the current SRI treatment and receive 12 weeks of augmentation. Participants completing the 12-week treatment may have the opportunity to continue treatment for up to one additional year. Treatment is provided at no cost.
Participants must have a DSM-IV-TR diagnosis of OCD as their primary disorder who have been on a stable treatment regimen of clomipramine, fluvoxamine, fluoxetine, paroxetine, or sertraline for at least 6 weeks may be eligible for this study. Six additional weeks of stable SRI treatment, without adequate clinical response, will be required prior to randomization, after which the participant will receive SRI plus study drug, for a total of 12 more weeks.
Exclusion critera include, but are not restricted to the following: